User:Michal Harel/AChBP

Acetylcholine binding protein (AChBP) is secreted by snails into cholinergic synapses where it modulates transmission by binding acetylcholine (ACh). It reveals the nature of the ligand-binding domains and the subunit interfaces of the nicotinic acetylcholine receptor. It binds agonists and antagonists of the nicotinic receptor and thus serves as an excellent model of the receptor molecule.

= AChBP - Apo proteins =

2w8e, 2byn – Aplysia  californica (AcAChBP)

1ux2, 1i9b – Lymnaea stagnalis (LsAChBP)

2bj0 – Bulinus truncatus

= AChBP + marine biotoxins =

2wzy – AcAChBP + 13-desmethyl spirolide C

2x00 - AcAChBP + gymnodimine A

= AChBP + partial agonists; Activate the receptor with partial efficacy =

2wn9 - AcAChBP + 4-OH-DMXBA

2wnc - AcAChBP + tropisetron

2wnj - AcAChBP + DMXBA

2wnl – AcAChBP + anabaseine [

= AChBP+ions; Mimicking the ion conductance of the receptor =

3gua – AcAChBP + sulfate

= AChBP+ neonicotinoids; Insecticides with lower affinity to mammals =

3c79 - AcAChBP + imidacloprid

2zju – LsAChBP + imidacloprid

3c84 – AcAChBP + thiacloprid

2zjv – LsAChBP+clothianidin

= AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction =

2pjz - AcAChBP+cocaine

2ph9 - AcAChBP+galanthamine

2w8f, 2w8g – AcAChBP + in silico compounds

= AChBP+ peptide inhibitors =

2c9t, 2byp, 2br8 - AcAChBP+conotoxin IMI

1yi5 – AcAChBP+cobratoxin

= AChBP+ nicotinic agonists enhance the action of the nicotinic acetylcholine receptor =

2pgz – AcAChBP+cocaine

2byr - AcAChBP+methyllycaconitine

2bys - AcAChBP+lobeline

= AChBP+ ligand homologs of the ligand acetylcholine =

1uv6 - LsAChBP+ carbamylcholine

1uw6 - LsAChBP+nicotine

= AChBP+others =

2br7 – AcAChBP+ HEPES